Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Food Allergy Severity Among US Adults

JAMA Netw Open; 2019 Jan 4; Gupta, et al

Better than 1 in 10 US adults are food allergic, whereas nearly 19% of adults believe that they have a food allergy, according to a new cross-sectional survey study. Surveys were administered via the Internet and telephone from October 9, 2015, to September 18, 2016. The primary outcome were self-reported food allergies and were considered convincing if reported symptoms to specific allergens were consistent with IgE-mediated reactions. Diagnosis history to specific allergens and food allergy-related health care use were also primary outcomes. Among the findings:

  • Surveys were completed by 40,443 adults (mean age, 46.6 years), with a survey completion rate of 51.2%.
  • Estimated convincing food allergy prevalence among US adults was 10.8% (>26 million); however, 19.0% of adults self-reported a food allergy.
  • Nearly half of food-allergic adults had at least 1 adult-onset food allergy, and 38% reported at least 1 food allergy-related emergency department visit in their lifetime.


Gupta RS, Warren CM, Smith BM, et al. Prevalence and severity of food allergies among US adults. JAMA Netw Open. 2019;2(1):e185630. doi:10.1001/jamanetworkopen.2018.5630.

This Week's Must Reads

TNF inhibitor prices rose despite increased drug class competition, San-Juan-Rodriguez A et al. JAMA Intern Med. 2019 Feb 18. doi: 10.1001/jamainternmed.2018.7656

List of medications linked to drug-induced lupus expands, Arnaud L et al. Ann Rheum Dis. 2019 Feb 4. doi: 10.1136/annrheumdis-2018-214598

HCV-infected patients in the ED should be tested for advanced liver fibrosis, Yu-Hsiang Hsieh Y-H. Am J Emerg Med. 2019;37[2]:286-90

Baby boomers account for more than 74% of chronic HCV cases, Moore KJ et al. J Infect Public Health. 2019 Jan-Feb;12(1):32-6.

PERT alerts improve pulmonary embolism outcomes, Benninghoff M. Critical Care Congress 2019, Abstract 490

Must Reads in Mixed Topics

Food Allergy Severity Among US Adults, JAMA Netw Open; 2019 Jan 4; Gupta, et al

Sexual Intercourse Among High School Students, MMWR; 2017 Jan 5; Ethier, Kann, et al

Coffee Consumption & Risk of Mortality, Ann Intern Med; ePub 2017 Jul 11; Park S, et al