Clinical Edge

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Prescription Medication Use & Depression

JAMA; 2018 Jun 12; Qato, Ozenberger, et al

The use of prescription medications that have depression as a potential adverse effect was common among US adults, with the use of multiple medications also associated with greater likelihood of simultaneous depression. This according to a cross-sectional survey study between 2005 and 2014 that measured the prevalence of any use and concurrent use of medications with a potential to cause depression and prevalence of depression. Researchers found:

  • 26,192 adults (mean age 46.2 years) were included in the study; 7.6% reported depression.
  • The estimated overall prevalence of US adults using medications with depression as a potential adverse effect was 37.2%.
  • The estimated prevalence of depression was 15% for those reporting use of ≥3 medications with depression as an adverse effect vs 4.7% for those not using such medications.

Citation:

Qato DM, Ozenberger K, Olfson M. Prevalence of prescription medications with depression as a potential adverse effect among adults in the United States. JAMA. 2018;319(22):2289–2298. doi:10.1001/jama.2018.6741.