Clinical Edge

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Inflammation Diminishes Quality of Life in NAFLD, Not Fibrosis

Key clinical point: A variety of demographic and disease-related factors contribute to poorer quality of life in patients with nonalcoholic fatty liver disease, most notably lobular inflammation.

Major finding: Multivariate analysis revealed an association between health-related quality of life and hepatic inflammation (P less than .05), but not fibrosis (P = .47).

Study details: A prospective quality of life study involving 304 patients with nonalcoholic fatty liver disease.

Disclosures: The study was funded by H2020. The investigators reported no conflicts of interest.


Huber Y et al. Clin Gastroenterol Hepatol. 2018 Dec 20. doi: 10.1016/j.cgh.2018.12.016.