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Type of Renal Dysfunction Affects Liver Cirrhosis Mortality Risk

Key clinical point: For non–status 1 patients with cirrhosis who are awaiting liver transplantation, type of renal dysfunction may be a key determinant of mortality risk.

Major finding: Patients with acute kidney injury and chronic kidney disease (AKI on CKD) had a 2.86-fold increased risk of death, compared with patients who had normal kidney function (subhazard ratio [SHR], 2.86).

Study details: A retrospective study involving 22,680 non–status 1 adults on the liver transplantation wait list.

Disclosures: The study was funded by a Paul B. Beeson Career Development Award and the National Institute of Diabetes and Digestive and Kidney Diseases. Dr. Verna disclosed relationships with Salix, Merck, and Gilead.


Cullaro et al. Clin Gastroenterol Hepatol. 2019 Feb 1. doi: 10.1016/j.cgh.2019.01.043.