Clinical Edge

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Supercooling extends donor liver viability by 27 hours

Key clinical point: A new supercooling process could extend ex vivo liver viability by more than a day, which could help relieve the organ donor–shortage crisis.

Major finding: Supercooling extended liver viability by 27 hours.

Study details: An ex vivo study testing viability of supercooled human livers for transplantation.

Disclosures: The study was funded by the National Institutes of Health and the Department of Defense. Five coauthors reported provisional patent applications related to the study, and one coauthor disclosed a financial relationship with Organ Solutions.


de Vries RJ et al. Nature Biotechnol. 2019 Sep 9. doi: 10.1038/s41587-019-0223-y.