Clinical Edge

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Meta-analysis finds no link between PPI use and risk of dementia

Key clinical point: A meta-analysis of evidence suggests no association between a diagnosis of dementia and PPI use.

Major finding: The incidence of dementia was not significantly increased among patients in the PPI-exposed group (OR, 1.08 (95% CI, 0.97-1.20; P = .18).

Study details: A meta-analysis of five studies comprising 472,933 patients.

Disclosures: The researchers reported having no financial disclosures.

Citation:

REPORTING FROM DDW 2019