Key clinical point: A gene associated with coagulation may play a key role in inflammatory bowel disease.
Major finding: Activity of the SERPINE1/PAI-1 pathway is associated with active and more severe colitis.
Study details: Transcriptome analysis of 1,800 intestinal biopsies from individuals with IBD, as well as mouse model studies.
Disclosures: The study was supported by the Crohn’s & Colitis Foundation. Three authors were supported by grants from the National Health & Medical Research Council, one by the Cancer Institute NSW, one by an Alpha Omega Alpha – Carolyn L. Kuckein Student Research Fellowship, and two by the National Institutes of Health. Four authors have a patent pending related to PAI-1. Two authors declared advisory board positions with pharmaceutical companies, including the manufacturer of a product used in the study. Three authors are employees of Janssen R&D.
Kaiko GE et al. Sci Transl Med. 2019. doi: 10.1126/scitranslmed.aat0852.