Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Subclinical Hypothyroidism Not Helped by Levothyroxine

Key clinical point: A study showed no significant differences between the effects of levothyroxine and placebo on fatigability.

Major finding: The between-group difference of perceived physical fatigability for patients taking levothyroxine and placebo was 0.2 (95% confidence interval, –1.8 to 2.1; P = 0.88).

Study details: A randomized, placebo-controlled study including 230 adults.

Disclosures: The study was funded by the European Union FP7 and the Swiss National Science Foundation. Merck KGaA Darmstadt (Germany) provided levothyroxine and the placebo. Dr. Stuber has no conflicts of interest.