Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Findings confirm link between methimazole and risk for acute pancreatitis

Key clinical point: Patients taking methimazole are at increased risk for acute pancreatitis.

Major finding: After 6 months of methimazole use, the odds ratio for acute pancreatitis was 2.02, with a nonsignificant risk elevation for propylthiouracil use of similar duration.

Study details: Danish registry-based, case-control and case-crossover study of 118,649 patients on antithyroid drugs.

Disclosures: Dr. Hegedüs reported no outside sources of funding and no conflicts of interest.


Hegedüs L et al. ATA 2019, Short Call Oral Abstract 6.