Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Severe Hypoglycemia, Poor Glycemic Control Fuel Fracture Risk in Older Patients With Type 2 Diabetes

Publish date:: November 13, 2019

Key clinical point: Older men and women with type 2 diabetes and poor glycemic control or episodes of severe hypoglycemia may be at higher risk for fractures.

Major finding: Patients faced a higher risk of fracture if they had two or more episodes of severe hypoglycemia (hazard ratio, 2.25; 95% confidence interval, 1.57-3.22) and one episode of severe hypoglycemia (HR, 1.57; 95% CI, 1.11-2.20).

Study details: A prospective analysis of fracture incidence in 2,755 men and 1,951 postmenopausal women in the Fukuoka Diabetes Registry between April 2008 and October 2010.

Disclosures: The study was funded in part by grants from The Japan Society for the Promotion of Science KAKENHI from the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Junior Scientist Development Grant supported by the Japan Diabetes Society; and the Lilly Research Grant Program for Bone & Mineral Research. The authors reported no relevant conflicts of interest.

Citation:

Komorita Y et al. Diabet Med. 2019 Sep 25. doi: 10.1111/dme.14142.

This Week's Must Reads

No clear-cut evidence of vedolizumab effect in retrospective study of primary sclerosing cholangitis,

Certolizumab may reduce uveitis flares, axSpA disease activity,

Bilateral mastectomy reduces second breast cancer risk, but not deaths,

Reward, decision-making brain regions altered in teens with obesity,

TULIP trials show clinical benefit of anifrolumab for SLE,

Must Reads in Diabetes

Nearly one in five U.S. adolescents have prediabetes,

Severe Hypoglycemia, Poor Glycemic Control Fuel Fracture Risk in Older Patients With Type 2 Diabetes,

Cardiometabolic risk burden is high in patients under 50 with type 2 diabetes,

Body weight influences SGLT2-inhibitor effects in type 1 diabetes,

Obesity Ups Type 2 Diabetes Risk Far More Than Lifestyle, Genetics,