Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Severe Hypoglycemia, Poor Glycemic Control Fuel Fracture Risk in Older Patients With Type 2 Diabetes

Publish date:: November 13, 2019

Key clinical point: Older men and women with type 2 diabetes and poor glycemic control or episodes of severe hypoglycemia may be at higher risk for fractures.

Major finding: Patients faced a higher risk of fracture if they had two or more episodes of severe hypoglycemia (hazard ratio, 2.25; 95% confidence interval, 1.57-3.22) and one episode of severe hypoglycemia (HR, 1.57; 95% CI, 1.11-2.20).

Study details: A prospective analysis of fracture incidence in 2,755 men and 1,951 postmenopausal women in the Fukuoka Diabetes Registry between April 2008 and October 2010.

Disclosures: The study was funded in part by grants from The Japan Society for the Promotion of Science KAKENHI from the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Junior Scientist Development Grant supported by the Japan Diabetes Society; and the Lilly Research Grant Program for Bone & Mineral Research. The authors reported no relevant conflicts of interest.

Citation:

Komorita Y et al. Diabet Med. 2019 Sep 25. doi: 10.1111/dme.14142.

This Week's Must Reads

Real-time, computer-aided detection system significantly improved adenoma detection,

High-def chromoendoscopy better for detecting dysplasias in patients with IBD,

PASDAS beats DAS28 in measuring psoriatic arthritis treat-to-target success,

Biopsies of ascending, descending colon alone detected microscopic colitis,

Cardiac CT scans can be used for osteoporosis screening,

Must Reads in Diabetes

Cognitive deficits complex in youths with type 2 diabetes,

Normal-weight prediabetes patients also benefit from lifestyle intervention,

T2D plus heart failure packs a deadly punch,

Dapagliflozin’s T2D renal protection extends to ‘fast decline’ of eGFR,