Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

How to reverse T2D with a crash diet

Key clinical point: Type 2 diabetes patients can shed significant weight quickly and eliminate the disease.

Major finding: Seventy-percent of patients with type 2 diabetes who lost more than 33 pounds on a liquid diet over a few months, and kept it off, were free of the disease at 2 years.

Study details: Open-label, randomized trial with 298 patients

Disclosures: The study was funded by Diabetes UK. Dr. Taylor reported financial relationships with Self, Wilmington Healthcare, Lilly Diabetes, and Novartis AG.


Zhyzhneuskaya SV et al., ADA 2019 abstract 66-OR


This study really proposes a new approach to people who have recent-onset type 2 diabetes. Our current approach is to recommend reduced caloric intake, exercise, and medication. It’s usually viewed as a progressive disease, with some individuals eventually requiring insulin. These remarkable results were obtained in the real world of clinical practice, not in a research study.

Alvin Powers, MD, is director of the diabetes center and a professor of medicine at Vanderbilt University, Nashville. He moderated the presentation and had no relevant disclosures.