Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Beyond PASI 100: striving for molecular clearance

Key clinical point: Molecular clearance of psoriasis at the gene expression level is the new frontier.

Major finding: The likelihood of experiencing residual psoriasis signs and symptoms, even after achieving a PASI 100 response, appears to depend upon the mechanism of action of the medication used to clear the skin.

Study details: This was a secondary analysis of the randomized, head-to-head VOYAGE 1 and 2 trials of guselkumab versus adalimumab for psoriasis.

Disclosures: The presenter serves as a scientific advisor to and paid clinical investigator for Janssen, which sponsored the study, as well as for roughly two dozen other pharmaceutical companies.


Blauvelt A. AAD 2020 LBCT.