Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

New SOFA version could streamline outcomes research

Key clinical point: eSOFA and SOFA had a similar predictive value for mortality.

Major finding: Among those with infections, 6.1% had a sepsis event based on at least a 2-point increase in SOFA score from baseline, compared with 4.4% identified by at least a 1-point increase in eSOFA score.

Study details: Retrospective study of 942,360 patients at 111 hospitals.

Disclosures: The Centers for Disease Control and Prevention and the Agency for Healthcare Research and Quality funded the study. Dr. Rhee and Dr. Khan have no relevant financial conflicts.


Rhee C et al. Crit Care Med. 2019;47(3):307-14.