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Racial Differences Between Estimated CRF & Stroke

Mayo Clin Proc; ePub 2018 Jun 11; Sui, et al

Nonexercise estimated cardiorespiratory fitness (eCRF) is a strong independent predictor of future strokes in whites, but not for blacks, with the results similar in men and women. A total of 24,162 participants from the REasons for Geographic And Racial Differences in Stroke study (54.8% women, 39.5% black; mean age 64.6 years) without stroke at enrollment between January 15, 2003 and October 30, 2007 were followed for incident stroke through March 31, 2016. Baseline eCRF in maximal metabolic equivalents was determined using nonexercised sex-specific algorithms and further grouped into age- and sex-specific tertiles. Researchers found:

  • Over a mean follow-up of 8.3 years, 945 (3.9%) incident strokes occurred (377 in blacks and 568 in whites).
  • The association between eCRF and stroke risk difference significantly by race.
  • In whites, the hazard ratio of stroke was 0.82 times lower in the middle tertile of eCRF than in the lowest tertile and was 0.54 times lower in the middle tertile of eCRF.
  • No association between eCRF and stroke risk was observed in blacks.


Sui X, Howard VJ, McDonnell MN, et al. Racial differences in the association between nonexercised estimated cardiorespiratory fitness and incident stroke. [Published online ahead of print June 11, 2018]. Mayo Clin Proc. doi:10.1016/j.mayocp.2018.05.002.