Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Low-Calorie Sweetened Beverages & Cardiometabolic Health

Circulation; ePub 2018 Jul 30; Johnson, et al

Self-reported consumption of both sugar-sweetened beverages (SSBs) and low-calorie sweetened beverages (LCS) beverages had been declining in the US; however, the use of alternatives to SSBs, with a focus on water, should be encouraged. This according to a new science advisory from the American Heart Association (AHA) that reviews evidence from observational studies and clinical trials assessing the cardiometabolic outcomes of LCS beverages. Among the AHA conclusions and recommendations:

  • The use of LCS beverages may be an effective strategy to help control energy intake and promote weight loss.
  • However, there is evidence on the potential adverse effects of LCS beverages relative to potential benefits.
  • Therefore, it is prudent to advise against prolonged consumption of LCS beverages by children.
  • In adults, LCS beverages may be a useful replacement strategy to reduce intake of SSBs.
  • The use of other alternatives to SSBs, with a focus on water (plain, carbonated, and unsweetened flavored), should be encouraged.


Johnson RK, Lichtenstein AH, Anderson CAM, et al. Low-calorie sweetened beverages and cardiometabolic health. A science advisory from the American Heart Association. [Published online ahead of print July 30, 2018]. Circulation. doi:10.1161/CIR.0000000000000569.

This Week's Must Reads

TNF inhibitor prices rose despite increased drug class competition, San-Juan-Rodriguez A et al. JAMA Intern Med. 2019 Feb 18. doi: 10.1001/jamainternmed.2018.7656

List of medications linked to drug-induced lupus expands, Arnaud L et al. Ann Rheum Dis. 2019 Feb 4. doi: 10.1136/annrheumdis-2018-214598

HCV-infected patients in the ED should be tested for advanced liver fibrosis, Yu-Hsiang Hsieh Y-H. Am J Emerg Med. 2019;37[2]:286-90

Baby boomers account for more than 74% of chronic HCV cases, Moore KJ et al. J Infect Public Health. 2019 Jan-Feb;12(1):32-6.

Must Reads in Cardiology

PAD tied to higher prevalence of LV diastolic dysfunction, Yanaka K et al. J Cardiol. 2019 Feb 18. doi: 10.1016/j.jjcc.2019.01.011

Possible mechanism for fluoroquinolone-induced aortopathy uncovered, Guzzardi DG et al. J Thorac Cardiovasc Surg. 2019;157:109-19.

Are Automated Office BP Readings More Accurate?, JAMA Intern Med; ePub 2019 Feb 4; Roerecke, et al

BMI Measurements and Intensive BP Management , Am J Med; ePub 2019 Feb 2; Oxlund, et al

Intensive BP Control & Risk of Dementia, JAMA; ePub 2019 Jan 28; SPRINT MIND Investigators