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Benefit of rivaroxaban after limb revascularization greatest in those with comorbid CAD

Key clinical point: Adding low-dose rivaroxaban to low-dose aspirin following revascularization for symptomatic lower-extremity peripheral artery disease provided significantly greater clinical benefit in patients with comorbid coronary artery disease.

Major finding: The relative risk reduction in the primary composite endpoint was 22% with rivaroxaban plus aspirin, compared with aspirin alone in patients with peripheral artery disease and coronary artery disease, twice that seen in those with peripheral artery disease only.

Study details: This was a secondary subgroup analysis of the 3-year, international, randomized, double-blind, placebo-controlled 6,564-patient VOYAGER PAD trial.

Disclosures: The trial was sponsored by Bayer and Janssen. The presenter reported receiving research grant support from those two companies as well as Amgen.


Hiatt WR. ESC 2020.