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Repeated ANA Testing After Negative Result of Little Diagnostic Value

Key clinical point: Repeated antinuclear antibody testing after a negative result has limited use for the diagnosis of ANA-associated rheumatologic conditions.

Major finding: With repeated testing, the results of 79% of ANA tests did not change, and the positive predictive value was very low at 0.01.

Study details: A retrospective, multicenter analysis of more than 36,000 ANA tests performed during a 7-year period (2011-2018) in Australia.

Disclosures: The presenting author Dr. Yeo reported having no conflicts of interest.


Yeo AL et al. Ann Rheum Dis. Jun 2019;78(suppl 2):76-7, Abstract OP0020. doi: 10.1136/annrheumdis-2019-eular.4517.