Clinical Edge

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Changes in sleep-wake timing accompany cerebral glucose hypometabolism and cognitive function

Key clinical point: Circadian rhythm alterations appear to precede Alzheimer’s-like neurodegeneration.

Major finding: Dysregulated sleep-wake patterns were associated with both decreased cerebral glucose metabolism and cognitive scores.

Study details: A 2-year, prospective study comprising 215 older adults.

Disclosures: Dr. Jeon had no financial disclosures.


Jeon SY et al. AAIC 2019, abstract 33543.