Key clinical point: Circadian rhythm alterations appear to precede Alzheimer’s-like neurodegeneration.
Major finding: Dysregulated sleep-wake patterns were associated with both decreased cerebral glucose metabolism and cognitive scores.
Study details: A 2-year, prospective study comprising 215 older adults.
Disclosures: Dr. Jeon had no financial disclosures.
Jeon SY et al. AAIC 2019, abstract 33543.