Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Females With Acne Stay on Spironolactone Longer Than Antibiotics

Key clinical point: Female patients with acne may benefit from continuing treatment with spironolactone longer than with oral antibiotics.

Major finding: The mean course duration was significantly longer among female patients treated with spironolactone than among those treated with an oral tetracycline.

Study details: A retrospective, observational study of 11,838 female patients with acne aged 12-40 years.

Disclosures: The study was funded in part by the National Institute of Arthritis and Musculoskeletal and Skin Diseases. Dr. Barbieri is supported by NIAMS and receives partial salary support through a Pfizer Fellowship in Dermatology Patient Oriented Research grant to the Trustees of the University of Pennsylvania.


Barbieri JS et al. J Am Acad Dermatol. 2019 Mar 21. doi: 10.1016/j.jaad.2019.03.036.