Simplifying or Switching ART in Treatment-Experienced Adults Living With HIV Paul G. Mariani, MDTze Shien Lo, MD Author and Disclosure Information [Show] Paul G. Mariani, MDUniversity of North Dakota School of Medicine & Health Sciences; Fargo, NDTze Shien Lo, MDUniversity of North Dakota School of Medicine & Health Sciences; Fargo, NDDisclosures. None. Question 1 of 5 A patient living with HIV who is heavily treatment-experienced and has multi-drug resistant virus, with genotypic and phenotypic resistance testing demonstrating resistance to both integrase and protease inhibitors, presents to discuss his treatment options. Tropism assay reveals the presence of CXCR4-using viruses, rendering CCR5 antagonists inactive. You opt to initiate fostemsavir as part of a salvage regimen.Which of the following best describes the mechanism of action of this novel drug? Choose one Monoclonal antibody blocking binding to primary receptor on CD4 cells gp120 attachment inhibitor Protease inhibitor Non-nucleotide reverse transcriptase inhibitor This quiz is not accredited for CME.