A 47-year-old Caucasian man with a history of coronary artery disease who underwent placement of a drug-eluting stent to the left anterior descending artery 3 months ago is referred to you for initial management of newly diagnosed HIV infection. He is not diabetic and does not smoke. His other medications include atorvastatin 40 mg daily, aspirin, clopidogrel, and metoprolol. He also takes pantoprazole 40 mg daily for significant long-standing gastroesophageal reflux disease. His baseline CD4 count is 525 cells/µL and HIV RNA is 55,000 copies/mL. Baseline liver function testing and blood urea nitrogen/creatinine ratio are within normal ranges.

He is interested in starting antiretroviral therapy as soon as possible, but would like to take as few pills as possible because he already takes several medications for his heart disease. Baseline resistance testing reveals fully sensitive virus without any meaningful resistance mutations.