Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Genital Wart Recurrence Among Unvaccinated Men

J Infect Dis; ePub 2018 Nov 2; Giuliano, et al

There is a high burden of genital wart (GW) recurrence among unvaccinated men across the lifespan and a need for vaccination to prevent multiple GW episodes, a new study found. The study was nested within a multinational prospective human papillomavirus (HPV) natural history study of men aged 18‒70 years in the US, Mexico, and Brazil, examined every 6 months for a median follow-up of 50.4 months. Subsequent GW events were defined as GWs detected after ≥16 weeks of the prior event. Among the findings:

  • 44% of men experience ≥1 GW following the initial episode.
  • Those with ≥2 subsequent events were at highest risk of continued GW experiences, with as high as 10 postinitial GW events.
  • The incidence rate of each subsequent GW increased with increasing events.
  • The proportion of GWs among HPV-6 and/or HPV-11-positive patients remained constant across events.
  • ~63‒69% were positive for ≥1 of the 9-valent HPV vaccine types.


Giuliano AR, Sirak B, Abrahamsen M, et al. Genital wart recurrence among men residing in Brazil, Mexico, and the United States. [Published online ahead of print November 2, 2018]. J Infect Dis. doi:10.1093/infdis/jiy533.