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IV vs Oral Antibiotics for Complicated Pneumonia

Pediatrics; ePub 2016 Nov 17; Shah, et al

Treatment failure rates between a peripherally inserted central venous catheter (PICC) and oral antibiotics for postdischarge treatment of complicated pneumonia in children did not differ; however, children with complicated pneumonia should preferentially receive oral antibiotics at discharge when effective oral options are available. This according to a recent multicenter retrospective cohort study that included 2,123 children aged ≥2 months and <18 years discharged with complicated pneumonia between 2009 and 2012. Primary outcome was treatment failure. Researchers found:

  • Among 2,123 children, 281 (13.2%) received antibiotics via PICC.
  • Treatment failure rates were 3.2% among PICC and 2.6% among oral antibiotic recipients.
  • PICC complications occurred in 7.1% of participants.
  • Adverse drug reactions occurred in 0.6% of children.
  • PICC antibiotic recipients had greater odds of adverse drug reaction in across hospital analysis (matched OR, 19.1).

Citation:

Shah SS, Srivastava R, Wu S, et al. Intravenous versus oral antibiotics for postdischarge treatment of complicated pneumonia. [Published online ahead of print November 17, 2016]. Pediatrics. doi:10.1542/peds.2016-1692.