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Clinical Features of Invasive Fungal Infection

Open Forum Infect Dis; ePub 2018 Jul 31; Webb, et al

In a large US healthcare network, invasive fungal infection (IFI) was not uncommon, affected a broad spectrum of patients, and was associated with high crude mortality, a recent study found. All records in the Intermountain Healthcare Enterprise Data Warehouse from 2006-2015 were queried for clinical data associated with IFI. Resulting data were overlaid in 124 different combinations to identify high-probability IFI cases. Researchers found:

  • 3,374 IFI occurred in 3,154 patients.
  • Mean incidence was 27.2 cases per 100,000 patients per year with a mean annual increase of 0.24 cases/100,000 patients.
  • Candidiasis was the most common IFI (55%).
  • Median age was 55 years; pediatric cases account for 13%.
  • Lymphopenia preceded IFI in 22.1% of patients.
  • Hospital admission occurred in 76.2% of patients, with median length of stay of 16 days.
  • All-cause mortality was 17.0% at 42 days and 28.8% at 1 year.


Webb BJ, Ferraro JP, Rea S, Stephanie Kaufusi, Goodman BE, Spalding J. Epidemiology and clinical features of invasive fungal infection in a U.S. Healthcare Network. [Published online ahead of print July 31, 2018]. Open Forum Infect Dis. doi:10.1093/ofid/ofy187.