Key clinical point: Targeted prophylaxis with posaconazole was effective in children with acute lymphoblastic leukemia undergoing induction chemotherapy.
Major finding: Posaconazole prophylaxis reduced the odds of invasive fungal infections by greater than 60% and prolonged infection-free survival significantly.
Study details: A single-center, retrospective cohort study of invasive fungal infection in 155 patients with newly diagnosed acute lymphoblastic leukemia.
Disclosures: The authors reported that they had no conflicts of interest.
Zhang T et al. J Microbiol, Immunol Infect. 2020 Aug 1. doi: 10.1016/j.jmii.2020.07.008.