Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Has Global Routine Vaccination Coverage Increased?

MMWR; 2016 Nov 18; Casey, Dumolard, et al

Global diphtheria-tetanus-pertussis vaccine (DTP3) coverage has not increased above 85% to 86% since 2010, with vaccination coverage varying widely across World Health Organization (WHO) regions, countries, and districts, a recent study found. Based on 2015 WHO and United Nations Children’s Fund (UNICEF) estimates, researchers found:

  • The first dose of polio vaccine (Pol3) has remained stable since 2010.
  • From 2014 to 2015, estimated global coverage with the second measles-containing vaccine dose (MCV2) increased from 39% to 43% by the end of the second year of life and from 58% to 61% when older age groups were included.
  • Global coverage was higher in 2015 than 2010 for newer or underused vaccines, including rotavirus vaccine, pneumococcal conjugate vaccine (PCV), rubella vaccine, Haemophilus influenzae type b (Hib) vaccine, and 3 doses of hepatitis B (HepB3) vaccine.


Casey RM, Dumolard L, Danovaro-Holliday MC, et al. Global routine vaccination coverage, 2015. MMWR Morb Mortal Wkly Rep. 2016;65:1270–1273. doi:10.15585/mmwr.mm6545a5.

This Week's Must Reads

Enterovirus in at-risk children associated with later celiac disease, Kahrs CR et al. BMJ. 2019 Feb 13. doi: 10.1136/bmj.l231

HCV-infected patients in the ED should be tested for advanced liver fibrosis, Yu-Hsiang Hsieh Y-H. Am J Emerg Med. 2019;37[2]:286-90

Baby boomers account for more than 74% of chronic HCV cases, Moore KJ et al. J Infect Public Health. 2019 Jan-Feb;12(1):32-6.

Possible mechanism for fluoroquinolone-induced aortopathy uncovered, Guzzardi DG et al. J Thorac Cardiovasc Surg. 2019;157:109-19.

HPV Vaccination Rates Low Among US Adolescents, J Infect Dis; ePub 2019 Jan 17; Bednarczyk, et al

Must Reads in International ID

Global Influenza-Associated Mortality on the Rise, Lancet; ePub 2017 Dec 13; Iuliano, et al

Efficacy of Corticosteroids in Tx of Pneumonia, Cochrane; ePub 2017 Dec 13; Stern, et al

Metformin Use During TB Treatment Evaluated, Clin Infect Dis; ePub 2017 Sep 19; Degner, et al

Burden of Community-Acquired Pneumonia in US, Clin Infect Dis; ePub 2017 Jul 28; Ramirez, et al

Temporal Incidence Trends of HCV in PWID, Clin Infect Dis; ePub 2017 Feb 24; Morris, et al