Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Seasonal Influenza A & Antiviral Tx for Patients

CDC Health Advisory; 2017 Dec 27; CDC

The Centers for Disease Control and Prevention (CDC) has issued a notice regarding increased influenza A(H3N2) activity and its clinical implications, a summary of influenza antiviral drug treatment recommendations, an update about approved treatment drugs and supply for the 2017-2018 season, and background information for patients about influenza treatment. Recommendations include:

  • CDC recommends antiviral medications for the treatment of influenza as an important adjunct to annual influenza vaccination.
  • All hospitalized, severely ill, and high-risk patients with suspected confirmed influenza should be treated with antivirals.
  • Antiviral treatment should be started as soon as possible after illness onset and should not be delayed even for a few hours to wait for the results of testing.
  • The most accurate influenza tests are molecular assays.
  • Neuraminidase inhibitors can benefit other individuals with influenza. 3 prescription neuraminidase inhibitor antiviral medications are recommended for use the US during the 2017-2018 season: iseltamivir (Tamiflu), zanamivir (Relenza), and peramivir (Rapivab).
  • Additional considerations for clinicians include bacterial infections and adverse events with antiviral use.

Citation:

Centers for Disease Control and Prevention. Seasonal influenza A(H3N2) activity and antiviral treatment of patients with influenza. December 27, 2017. https://emergency.cdc.gov/han/han00409.asp. Accessed December 30, 2017.

This Week's Must Reads

IDSA Updates Seasonal Influenza Guidelines, Clin Infect Dis; ePub 2018 Dec 19; Uyeki, et al

Efficacy of Cell-Cultured & Egg-Based Influenza Vaccines, J Infect Dis; ePub 2018 Dec 18; Izurieta, et al

Prevention of Influenza Hospitalization in US Adults, J Infect Dis; ePub 2018 Dec 14; Ferdinands, et al

Clinical & Virologic & Characteristics of Zika Virus Infection, Open Forum Infect Dis; ePub 2018 Dec 19; El Sahly, et al

Importations of Measles Virus in the US, J Infect Dis; ePub 2018 Dec 9; Lee, et al

Must Reads in Influenza

IDSA Updates Seasonal Influenza Guidelines, Clin Infect Dis; ePub 2018 Dec 19; Uyeki, et al

Efficacy of Cell-Cultured & Egg-Based Influenza Vaccines, J Infect Dis; ePub 2018 Dec 18; Izurieta, et al

Prevention of Influenza Hospitalization in US Adults, J Infect Dis; ePub 2018 Dec 14; Ferdinands, et al

RSV vs Influenza in Hospitalized Older Adults, Clin Infect Dis; ePub 2018 Nov 19; Ackerson, et al

Immunocompromised Children with Influenza, J Pediatric Infect Dis Soc; ePub 2018 Oct 25; Collins, et al