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Influenza Effects in Patients with Heart Failure

JACC Heart Fail; ePub 2019 Jan 2; Panhwar, et al

Among patients with heart failure (HF), influenza infection is associated with increased in-hospital morbidity and mortality, a new study found. Researchers analyzed the 2013 to 2014 National Inpatient Sample database for all adult patients aged ≥18 years admitted with HF with and without concomitant influenza infection. Outcomes included in-hospital mortality, in-hospital complications, length of stay (LOS), and average hospital costs. They found:

  • Of 8,189,119 all-cause hospitalizations in patients with HF, 54,590 (0.67%) had concomitant influenza infection.
  • Patients with concomitant influenza had higher incidence of in-hospital mortality, acute respiratory failure, acute respiratory failure requiring mechanical ventilation, acute kidney injury (AKI), and AKI requiring dialysis.
  • Patients with influenza also had longer mean LOS, but similar hospital costs.


Panhwar MS, Kalra A, Gupta T, et al. Effect of influenza on outcomes in patients with heart failure. [Published online ahead of print January 2, 2019]. JACC Heart Fail. doi:10.1016/j.jchf.2018.10.011.