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Immunocompromised Children with Influenza

J Pediatric Infect Dis Soc; ePub 2018 Oct 25; Collins, et al

Immunocompromised children hospitalized with influenza received intensive care less frequently but had a longer hospitalization duration than nonimmunocompromised children, a new study found. Researchers analyzed data from the 2011-2012 through 2014-2015 influenza seasons and compared clinical features and outcomes between the immunocompromised and nonimmunocompromised children aged <18 years hospitalized with laboratory-confirmed community-acquired influenza. They found:

  • Among 5,262 hospitalized children, 242 (4.6%) were immunocompromised; receipt of nonsteroidal immunosuppressive therapy, cancer, and solid organ transplantation were most common.
  • Immunocompromised children were older, more likely to have comorbidity, and more likely to have received an influenza vaccination and early antiviral treatment.
  • In multivariable analyses, immunocompromised children were less likely to receive intensive care and had a slightly longer duration of hospitalization.
  • Death was uncommon in both groups.

Citation:

Collins JP, Campbell AP, Openo K, et al. Clinical features and outcomes of immunocompromised children hospitalized with laboratory-confirmed influenza in the United States, 2011–2015. [Published online ahead of print October 25, 2018]. J Pediatric Infect Dis Soc. doi:10.1093/jpids/piy101.