Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Efficacy of Cell-Cultured & Egg-Based Influenza Vaccines

J Infect Dis; ePub 2018 Dec 18; Izurieta, et al

Among a cohort of elderly US adults, a modest vaccine effectiveness (VE) difference between cell-cultured and egg-based vaccines only partially explains low overall VE, suggesting egg adaption is not the main contributor to the low VE found in this population. This according to a retrospective cohort study on beneficiaries aged ≥65 years who received an influenza vaccine during the 2017‒2018 season. Researchers compared effectiveness of cell-cultured and egg-based vaccines. They found:

  • Of >13 million Medicare beneficiaries, relative vaccine effectiveness (RVE) for cell-cultured vaccines relative to egg-based quadrivalent vaccines was 10%.
  • The estimate was 16.5% in a mid-season interim analysis.
  • In a 5-way comparison, cell-cultured and egg-based high-does vaccines were more effective than egg-based quadrivalent vaccines.

Citation:

Izurieta HS, Chillarige Y, Kelman J, et al. Relative effectiveness of cell-cultured and egg-based influenza vaccines among the U.S. elderly, 2017–18. [Published online ahead of print December 18, 2018]. J Infect Dis. doi:10.1093/infdis/jiy716.

This Week's Must Reads

Enterovirus in at-risk children associated with later celiac disease, Kahrs CR et al. BMJ. 2019 Feb 13. doi: 10.1136/bmj.l231

HCV-infected patients in the ED should be tested for advanced liver fibrosis, Yu-Hsiang Hsieh Y-H. Am J Emerg Med. 2019;37[2]:286-90

Baby boomers account for more than 74% of chronic HCV cases, Moore KJ et al. J Infect Public Health. 2019 Jan-Feb;12(1):32-6.

Possible mechanism for fluoroquinolone-induced aortopathy uncovered, Guzzardi DG et al. J Thorac Cardiovasc Surg. 2019;157:109-19.

HPV Vaccination Rates Low Among US Adolescents, J Infect Dis; ePub 2019 Jan 17; Bednarczyk, et al

Must Reads in Influenza

Influenza Effects in Patients with Heart Failure, JACC Heart Fail; ePub 2019 Jan 2; Panhwar, et al

IDSA Updates Seasonal Influenza Guidelines, Clin Infect Dis; ePub 2018 Dec 19; Uyeki, et al

Efficacy of Cell-Cultured & Egg-Based Influenza Vaccines, J Infect Dis; ePub 2018 Dec 18; Izurieta, et al

Prevention of Influenza Hospitalization in US Adults, J Infect Dis; ePub 2018 Dec 14; Ferdinands, et al

RSV vs Influenza in Hospitalized Older Adults, Clin Infect Dis; ePub 2018 Nov 19; Ackerson, et al