Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Early Oseltamivir Therapy & Shortened Hospitalization

Clin Infect Dis; ePub 2018 Oct 9; Katzen, et al

Over multiple influenza seasons, early neuraminidase inhibitor (NAI) therapy was associated with shorter hospital length of stay (LOS) in patients admitted with influenza, a recent study found. Researchers conducted a retrospective cohort study of all adults hospitalized in a metropolitan tertiary care hospital with confirmed influenza from April 2009 to March 2014. They found:

  • 699 patients were admitted with influenza during the 5 influenza seasons.
  • 582 (83.4%) patients received NAI therapy, but only 26.0% received the first dose within 6 hours of hospitalization.
  • Early NAI was associated with shorter hospital LOS.
  • No patients died in the early NAI group vs 18 deaths in the patients receiving NAI after 6 hours and 4 deaths in patients not receiving NAI.


Katzen J, Kohn R, Houk JL, Ison MG. Early oseltamivir after hospital admission is associated with shortened hospitalization: A five-year analysis of oseltamivir timing and clinical outcomes. [Published online ahead of print October 9, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy860.

Must Reads in Influenza

Influenza Vaccination Effectiveness in the US, Clin Infect Dis; ePub 2019 Feb 2; Rolfes, et al

Influenza Associated Outcomes in Pregnancy, J Infect Dis; ePub 2019 Jan 23; Prasad, et al

Influenza Effects in Patients with Heart Failure, JACC Heart Fail; ePub 2019 Jan 2; Panhwar, et al

IDSA Updates Seasonal Influenza Guidelines, Clin Infect Dis; ePub 2018 Dec 19; Uyeki, et al

Efficacy of Cell-Cultured & Egg-Based Influenza Vaccines, J Infect Dis; ePub 2018 Dec 18; Izurieta, et al