Clinical Edge

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Zika virus syndrome may adversely affect children normocephalic at birth

Key clinical point: Head circumference should be carefully monitored in children with congenital Zika virus syndrome.

Major finding: Among the children with normocephaly at birth, 68% had abnormal neurologic findings by age 3 years.

Study details: The retrospective analysis involved 215 children with laboratory-confirmed antenatal Zika virus exposure.

Disclosures: The study was funded by grants from the National Institute of Allergy and Infectious Diseases, the National Eye Institute, and the Thrasher Foundation and by awards from Brazil’s National Council of Scientific and Technological Development; Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro. Some individual investigators received fees and grants from these and other organizations.


Cranston JS et al. JAMA Netw Open. 2020 July 7;3(7):e209303.