Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Sex Differences in HIV-associated Cognitive Impairment

AIDS; ePub 2018 Oct 4; Sundermann, et al

Women were at greater risk of HIV-associated cognitive impairment compared to men, a recent study found. The observational cohort study included 1,361 HIV-positive (204 women) and 702 HIV-negative (214 women) participants aged 18‒79 years from the UCSD HIV Neurobehavioral Research Program. Demographically-corrected standardized T-scores from 15 neuropsychological tests were used to calculate domain-specific and global deficit scores. Researchers found:

  • HIV-associated neurocognitive impairment was more prevalent in women vs men.
  • The association between HIV-seropositivity and higher likelihood of neurocognitive impairment was stronger in women vs men.
  • These results were specific to black women.
  • Higher rates of HIV-associated neurocognitive impairment in women vs men may reflect differences in educational quality.


Sundermann EE, Heaton RK, Pasipanodya E, et al. Sex differences in HIV-associated cognitive impairment: An observational cohort study. [Published online ahead of print October 4, 2018]. AIDS. doi:10.1097/QAD.0000000000002012.

This Week's Must Reads

Enterovirus in at-risk children associated with later celiac disease, Kahrs CR et al. BMJ. 2019 Feb 13. doi: 10.1136/bmj.l231

HCV-infected patients in the ED should be tested for advanced liver fibrosis, Yu-Hsiang Hsieh Y-H. Am J Emerg Med. 2019;37[2]:286-90

Baby boomers account for more than 74% of chronic HCV cases, Moore KJ et al. J Infect Public Health. 2019 Jan-Feb;12(1):32-6.

Possible mechanism for fluoroquinolone-induced aortopathy uncovered, Guzzardi DG et al. J Thorac Cardiovasc Surg. 2019;157:109-19.

HPV Vaccination Rates Low Among US Adolescents, J Infect Dis; ePub 2019 Jan 17; Bednarczyk, et al

Must Reads in HIV

Postpartum Engagement in HIV Care , Open Forum Infect Dis; ePub 2019 Jan 19; Oliver, et al

Frailty & Adverse Health Outcomes in Aging Adults with HIV, Clin Infect Dis; ePub 2018 Dec 24; Kelly, et al

HCV Treatment Eligibility Among People with HIV, Clin Infect Dis; ePub 2019 Jan 7; Breskin, et al

HIV-associated Cryptococcal Meningitis at Higher CD4 Counts, J Infect Dis; ePub 2018 Oct 16; Tugume, et al

Sex Differences in HIV-associated Cognitive Impairment, AIDS; ePub 2018 Oct 4; Sundermann, et al