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Predictors of Longitudinal PrEP Adherence Among MSM

J Infect Dis; ePub 2018 Jun 22; Pasipanodya, et al

The use of text-reported pre-exposure prophylaxis (PrEP) adherence was favorable among men who have sex with men (MSM), a recent study found. The randomized controlled trial of text-messaging vs standard of care for PrEP adherence included 181 MSM who received once-daily tenofovir disoproxil fumarate/emtricitabine and daily adherence texts for 48 weeks. Growth Mixture Modeling (GMM) was used to identify subgroups of individuals with similar trajectories of text-reported adherence. Between-groups differences in pharmacologic measures of adherence as well as predictors and study-end attitudes associated with group membership, were examined. Researchers found:

  • 4 trajectories of text-reported adherence were identified.
  • Classes with higher text-reported adherence had higher drug concentrations.
  • Younger age and minority race were associated with lower adherence.
  • Individuals in classes with lower adherence had greater baseline levels of depression, substance abuse concerns, and sexual risk.
  • Differences in study satisfaction were also associated with adherence.


Pasipanodya EC, Jain S, Sun X, et al. Trajectories and predictors of longitudinal PrEP adherence among men who have sex with men. [Published online ahead of print June 22, 2018]. J Infect Dis. doi:10.1093/infdis/jiy368.