Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Mobile Health Intervention for PrEP in Young MSM

Clin Infect Dis; ePub 2018 Sep 15; Liu, et al

Young men who have sex with men (MSM) who are at risk for HIV and received a text-messaging pre-exposure prophylaxis (PrEP) intervention had higher study retention and PrEP adherence as measured by blood drug levels. Researchers conducted a randomized controlled trial to evaluate the impact of the interactive text-messaging PrEP support intervention (PrEPmate) on study retention and PrEP adherence. Young individuals at risk for HIV acquisition initiating PrEP within Chicago’s safety-net hospital system were randomized 2:1 to receive PrEPmate or standard of care (SoC) for 36 weeks. They found:

  • Across all visits, participants who received PrEPmate were more likely to attend study visits and have tenofovir diphosphate (TFV-DP) levels consistent with ≥4 doses/week.
  • Overall, 88% of participants reported PrEPmate to be very/somewhat helpful, and 92% would recommend it to others.
  • PrEPmate efficacy did not differ significantly by age, race/ethnicity, education, or insurance.


Liu AY, Vittinghoff E, von Felten P, et al. Randomized controlled trial of a mobile health intervention to promote retention and adherence to pre-exposure prophylaxis among young people at risk for human immunodeficiency virus: The EPIC Study. [Published online ahead of print September 15, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy810.

This Week's Must Reads

Possible mechanism for fluoroquinolone-induced aortopathy uncovered, Guzzardi DG et al. J Thorac Cardiovasc Surg. 2019;157:109-19.

HPV Vaccination Rates Low Among US Adolescents, J Infect Dis; ePub 2019 Jan 17; Bednarczyk, et al

Variability in Antibiotic Prescribing for ARIs, Open Forum Infect Dis; ePub 2019 Jan 18; Jung, et al

Mumps in a Highly Vaccinated Marshallese Community, Lancet Infect Dis; ePub 2019 Jan 8; Fields, et al

Postpartum Engagement in HIV Care , Open Forum Infect Dis; ePub 2019 Jan 19; Oliver, et al

Must Reads in HIV

Postpartum Engagement in HIV Care , Open Forum Infect Dis; ePub 2019 Jan 19; Oliver, et al

Frailty & Adverse Health Outcomes in Aging Adults with HIV, Clin Infect Dis; ePub 2018 Dec 24; Kelly, et al

HCV Treatment Eligibility Among People with HIV, Clin Infect Dis; ePub 2019 Jan 7; Breskin, et al

HIV-associated Cryptococcal Meningitis at Higher CD4 Counts, J Infect Dis; ePub 2018 Oct 16; Tugume, et al

Sex Differences in HIV-associated Cognitive Impairment, AIDS; ePub 2018 Oct 4; Sundermann, et al