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Meningococcal Disease in Patients with HIV

Open Forum Infect Dis; ePub 2016 Oct 24; Harris, et al

There is a higher incidence of meningococcal disease in individuals with HIV infection meeting the AIDS surveillance case definition compared to the general adult population, a recent study found. The study examined persons with meningococcal disease with HIV infection reported from 2000 through 2008 from 9 US sites participating in an active population-based surveillance system for meningococcal disease. Researchers found:

  • 33 cases of meningococcal disease in individuals with HIV infection were reported (2% of all reported cases).
  • 75.8% persons with HIV infection were adult males aged 25 to 64 years.
  • Case fatality ratios were similar among HIV-infected and HIV-uninfected persons among all meningococcal disease cases aged 25 to 64 years.
  • The cumulative, mean incidence of meningococcal disease among patients aged 25 to 64 years with HIV infection ever classified as AIDS was 3.5 cases per 100,000 person years, compared to 0.3 cases per 100,000 person years for persons of the same age group not reported to have AIDS (RR=12.9).


Harris CM, Wu HM, Li J, et al. Meningococcal disease in patients with HIV infection—A review of cases reported through active surveillance in the United States, 2000-2008. [Published online ahead of print October 24, 2016]. Open Forum Infect Dis. doi:10.1093/ofid/ofw226.