Clinical Edge

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Integrase Inhibitors for HIV Can Lead To Weight Gain

Key clinical point: You’re not imagining things: Integrase inhibitors really do pack on the weight.

Major finding: At 2 and 5 years, patients started on integrase inhibitors gained 4.9 and 6 kg, respectively, over their predicted weight, compared with 3.3 and 4.3 kg for NNRTIs, and 4.4 and 5.1 kg for PIs, after adjustment for age, sex, race, cohort site, HIV acquisition mode, ART initiation year, and baseline weight, HIV-1 RNA, and CD4 cell count.

Study details: Review of 24,001 HIV patients.

Disclosures: The work was funded by Gilead. The lead investigator didn’t report any disclosures.


Bourgi K et al. CROI 2019, Abstract 670.