Increased inflammation and lower hormone levels were observed in HIV-infected frail men, but independent of comorbid conditions, a recent study found. Researchers studied HIV-infected frail men (n=155) who were matched to non-frail, HIV-infected (n=141), and HIV-uninfected (n=150) men by age, calendar year, and antiretroviral therapy (ART) use. Frailty was defined by ≥3 frailty-related phenotype criteria at ≥2 visits, or at 1 visit with ≥1 criteria at ≥2 visits. They found:
- Frailty was associated with higher IL-6 and hs-CRP and lower free testosterone and DHEA in multivariate analyses adjusted for covariates.
- Conversely, HIV infection but not frailty, was associated with significantly greater immune senescence and immune activation.
The authors concluded that interventions targeting these pathways should be evaluated to determine the impact on prevention or reversal of frailty among HIV-infected men.
Erlandson KM, Ng D, Jacobson LP, et al. Inflammation, immune activation, immunosenescence, and hormonal biomarkers in the frailty-related phenotype of men with or at risk for HIV. [Published online ahead of print October 31, 2016]. J Infect Dis. doi:10.1093/infdis/jiw523.