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Frailty & Adverse Health Outcomes in Aging Adults with HIV

Clin Infect Dis; ePub 2018 Dec 24; Kelly, et al

Among aging adults with HIV, baseline frailty is associated with multiple adverse health outcomes, including cardiovascular disease (CVD), diabetes mellitus (DM), and bone disease, a new study found. Participants underwent frailty evaluations as baseline and then annually. Clinical outcomes of mortality, incident CVD events, DM, and bone disease events were recorded throughout the study period. Researchers evaluated associations between baseline frailty, change in frailty score over 48 weeks, and each clinical outcome. They found:

  • Among 821 men and 195 women (median age 51 years), 62 (6%) were frail at baseline.
  • Frailty scores increased in ≥1 components among 194 participants (19%) from baseline to 48 weeks.
  • Increased in frailty score was associated with mortality, but not with the other clinical outcomes.


Kelly SG, Wu K, Tassiopoulos K, et al, for the ACTG A5322 Study Team. Frailty is an independent risk factor for mortality, cardiovascular disease, bone disease and diabetes among aging adults with HIV. Clin Infect Dis. doi:10.1093/cid/ciy1101.