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Pregnancy Outcomes in Women with HBV

Open Forum Infect Dis; ePub 2018 Jun 9; Bajema, et al

Hepatitis B virus (HBV) infection was not associated with adverse pregnancy outcomes in a low-burden setting in the US, a recent study found. Researchers conducted a retrospective population-based study linking birth certificate and hospital discharge records from 1992 to 2014. Among pregnant women with HBV (n=4,391) and a hepatitis B negative group (n=22,410), they compared the risk of gestational diabetes, preeclampsia, eclampsia, placenta previa, preterm delivery, low birthweight, small-for-gestational age (SGA), and large-for-gestational age (LGA) using multivariate logistic regression. They found:

  • HBV-infected women were more likely to be Asian, foreign-born, and older in age; they were less commonly overweight or obese.
  • There was a lower risk of SGA infants among HBV-infected women (adjusted risk ratio [aRR]: 0.79).
  • The risk of other adverse outcomes was not significantly different between HBV-infected women and negative women.


Bajema KL, Stankiewicz Karita HC, Tenforde MW, Hawes SE, Heffron R. Maternal hepatitis B infection and pregnancy outcomes in the United States: A population-based cohort study. [Published online ahead of print June 9, 2018]. Open Forum Infect Dis. doi:10.1093/ofid/ofy134.