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Mortality in US Patients with Chronic HBV

Clin Infect Dis; ePub 2018 Jul 28; Bixler, et al

Patients in the US with chronic hepatitis B (CHB) infection die at a younger age and at higher rates from all causes and liver-related causes compared to the general population, a recent study found. Researchers analyzed data from CHB patients seen in the Chronic Hepatitis Cohort Study (CHeCS) between January 1, 2006, and December 31, 2013 and compared overall and cause-specific death rates and mean age at death between CHeCS CHB decedents and US decedents. They found:

  • A total of 4,389 CHB patients were followed for a mean of 5.38 years through December 31, 2014; 492 (11%) CHB patients died after a mean follow-up of 3.00 years.
  • Compared to survivors, decedents were older, more likely to be white (40.6%), African-American (27.1%) or male (74.2%), and more likely to have cirrhosis, diabetes, alcohol abuse, hepatocellular carcinoma, or liver transplant.
  • Survivors were more likely to be Asian (48.8%).
  • CHB patients died at an average age of 59.8 years, 14 years younger than the general US population and at higher rates for all causes (RR=1.854).


Bixler D, Zhong Y, Ly KN, Moorman AC, et al. Mortality among patients with chronic hepatitis B (CHB) infection: The Chronic Hepatitis Cohort Study (CHeCS). [Published online ahead of print July 28, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy598.