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Mitochondrial Damage, Iron Accumulation From HCV Linked to HCC Development

Key clinical point: Mitochondrial damage, iron accumulation from hepatitis C virus (HCV) are linked to the development of hepatocellular carcinoma.

Major finding: The precise mechanisms of HCV-induced mitochondrial damage and iron dysregulation remain unclear.

Study details: Literature of mitochondrial damage and iron metabolic dysregulation caused by HCV, and its relation to hepatocellular carcinoma.

Disclosures: Support was from the Research Program on Hepatitis from the Japan Agency for Medical Research and Development. The authors reported no disclosures.


Keisuke H et al Free Radic Biol Med. 2019;133:193-9.