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Despite HCV cure, liver cancer-associated genetic changes persist

Key clinical point: Despite HCV cure, liver tissue showed the presence of HCC-associated genetic changes.

Major finding: Chronic HCV infection induces H3K27ac modifications associated with HCC risk that persists after HCV cure.

Study details: Liver tissue samples from patients with and without chronic HCV-cure plus controls were assessed.

Disclosures: The authors declared that they had no conflicts.


Hamdane N, et al., 2019; Gastroenterology 156:2313–29.