Key clinical point: Despite HCV cure, liver tissue showed the presence of HCC-associated genetic changes.
Major finding: Chronic HCV infection induces H3K27ac modifications associated with HCC risk that persists after HCV cure.
Study details: Liver tissue samples from patients with and without chronic HCV-cure plus controls were assessed.
Disclosures: The authors declared that they had no conflicts.
Hamdane N, et al., 2019; Gastroenterology 156:2313–29.