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Low Plasma 25(OH)D and Risk of Sepsis

Open Forum Infect Dis; ePub 2018 Sep 18; Kempker, et al

Low plasma 25-hydroxyvitamin D 25(OH)D measured at the time of relative health was independently associated with increased risk of sepsis in a cohort of community-dwelling US adults. Participants were selected from the Reasons for Geographic and Racial Differences in Stroke study (REGARDS), a US cohort of 30,239 adults aged ≥45 years. Researchers measured baseline plasma 25(OH)D in 711 sepsis cases and in 992 participants randomly selected from the cohort. They found:

  • Median age of participants in the study sample was 65 years (41% black, 45% male).
  • Mean plasma 25-hydroxyvitamin D concentrations was 25.8 ng/ml with 31% of individuals <20 ng/ml.
  • The adjusted risk of community-acquired sepsis was higher for each lower category of baseline 25(OH)D.
  • Results did not differ in analyses stratified by race or age.


Kempker JA, Panwar B, Judd SE, Jenny NS, Wang HE, Gutiérrez OM. Plasma 25-hydroxyvitamin D and the longitudinal risk of sepsis in the REGARDS cohort. [Published online ahead of print September 18, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy794.