Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

ID Consultation & Clinical Outcomes in SAB

Open Forum Infect Dis; ePub 2018 Jun 14; Yousaf, et al

In patients at low risk for endocarditis, infectious disease consultation was associated with significantly longer duration of intravenous (IV) antibiotics and non-significantly reduced in-hospital and 30-day mortality, a recent study found. The retrospective cohort study included patients admitted to any of 3 hospitals in a specified healthcare system. Primary outcomes were in-hospital mortality, 30-day mortality starting after hospital discharge, length of stay starting from the day the first positive blood culture was drawn, ICU length of stay starting from the day the first positive blood culture was drawn, and readmission within 90 days of the discharge date. Researchers found:

  • Patients at low risk for endocarditis and who had no secondary site of infection was associated with a longer course of antibiotics (median duration of IV antimicrobial therapy of 31 days and 15 days in those with and without ID consultation).
  • These patients also had reduced in-hospital mortality and reduced 30-day mortality after discharge.
  • ID consultation was also associated with higher readmission rate within 90 days of discharge (46% and 34% with and without ID consultation), respectively.

Citation:

Yousaf A, Baird GL, Mermel L. Association of infectious disease consultation with clinical outcomes in patients with Staphylococcus aureus bacteremia at low risk for endocarditis. [Published online ahead of print June 14, 2018]. Open Forum Infect Dis. doi:10.1093/ofid/ofy142.

Must Reads in Healthcare-acquired Infections

Antibiotic Use and Hospital Onset CDI Infection, Clin Infect Dis; ePub 2019 Mar 1; Kazakova, et al

Decolonization Lowers Postdischarge Infection Risk, N Engl J Med; 2019 Feb 14; Huang, et al

30-Day Readmission After S. aureus Bacteremia, Clin Infect Dis; ePub 2019 Feb 11; Inagaki, et al

Bloodstream Infections in Hospitalized Children, Clin Infect Dis; ePub 2018 Dec 9; Spaulding, et al