Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

In-Hospital Infective Endocarditis After TAVR

J Hosp Infect; ePub 2018 May 24; Yeo, et al

After transcatheter aortic valve replacement (TAVR), infective endocarditis (IE) occurred in 0.3% of patients during the same hospitalization, resulting in higher rates of adverse outcomes including mortality. Using the National Inpatient Sample database, researchers identified all patients who underwent TAVR between 2012 and 2014. Multivariate logistic regression was performed to identify the predictors of in-hospital IE after TAVR. Among the details:

  • Of the 41,025 patients who received TAVR, 120 patients (0.3%) developed in-hospital IE.
  • Patients who developed in-hospital IE after TAVR had significantly higher rates of deaths, septic shock, cardiogenic shock, acute kidney requiring hemodialysis, bleeding requiring transfusion, myocardial infarction, and permanent pacemaker removal vs those without IT.
  • Patients with younger age, drug abuse history, or HIV infection are at greater risk of in-hospital IE following TAVR.


Yeo I, Kim LK, Park SO, Wong SC. In-hospital infective endocarditis following transcatheter aortic valve replacement: a cross sectional study of National Inpatient Sample database in the United States. [Published online ahead of print May 24, 2018]. J Hosp Infect. doi:10.1016/j.jhin.2018.05.014.

This Week's Must Reads

IDSA Updates Seasonal Influenza Guidelines, Clin Infect Dis; ePub 2018 Dec 19; Uyeki, et al

Efficacy of Cell-Cultured & Egg-Based Influenza Vaccines, J Infect Dis; ePub 2018 Dec 18; Izurieta, et al

Prevention of Influenza Hospitalization in US Adults, J Infect Dis; ePub 2018 Dec 14; Ferdinands, et al

Clinical & Virologic & Characteristics of Zika Virus Infection, Open Forum Infect Dis; ePub 2018 Dec 19; El Sahly, et al

Importations of Measles Virus in the US, J Infect Dis; ePub 2018 Dec 9; Lee, et al

Must Reads in Healthcare-acquired Infections

Bloodstream Infections in Hospitalized Children, Clin Infect Dis; ePub 2018 Dec 9; Spaulding, et al

Disparities and Risk Factors for Septicemia Deaths , Open Forum Infect Dis; ePub 2018 Nov 15; Kempker, et al

Predicting Severe Outcomes in US Norovirus Outbreaks, J Infect Dis; ePub 2018 Nov 15; Burke, et al

GI Microbiota Disruption with CRPA in ICU Patients, Clin Infect Dis; ePub 2018 Nov 1; Pettigrew, et al

Better Management of OPAT Can Reduce Readmissions, Clin Infect Dis; ePub 2018 Sep 21; Shah, et al