Colonization is a risk factor for Staphylococcus aureus (S. aureus) disease in the general population; however, there is marked heterogeneity between studies and further analysis is needed to identify the major sources of this variance. This according to a meta-analysis of observational studies that included 12 articles on 6,998 subjects who met eligibility criteria. Researchers found:
- Overall, subjects colonized with S. aureus were more likely to progress to disease than those who were non-colonized (OR, 1.87).
- A larger effect was observed with methicillin-resistant S. aureus colonization.
- However, the methicillin-resistant S. aureus colonization was not associated with greater odds of disease.
- Heterogeneity was present across all studies in all subgroups: S. aureus, MRSA, and MSSA.
Kim MW, Greenfield BK, Snyder RE, Steinmaus CM, Riley LW. The association between community-associated Staphylococcus aureus colonization and disease: a meta-analysis. [Published online ahead of print February 21, 2018]. BMC Infect Dis. doi:10.1186/s12879-018-2990-3.
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Antibiotic Use and Hospital Onset CDI Infection, Clin Infect Dis; ePub 2019 Mar 1; Kazakova, et al
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30-Day Readmission After S. aureus Bacteremia, Clin Infect Dis; ePub 2019 Feb 11; Inagaki, et al
Bloodstream Infections in Hospitalized Children, Clin Infect Dis; ePub 2018 Dec 9; Spaulding, et al