Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

CDI Incidence in US Hospitals Among Age Groups

BMC Infect Dis; ePub 2016 Nov 17; Pechal, et al

Clostridum difficile infection (CDI) incidence, mortality, and hospital length of stay (LOS) in US hospitals were highest in the elderly adult population, a recent study found. The retrospective analysis of the US National Hospital Discharge Surveys from 2001 to 2010 included data representing 2.3 million hospital discharges for CDI over the study period. Patients were stratified by age: <18 years (pediatrics), 18 to 64 years (adults), and ≥65 years (elderly adults). Researchers found:

  • CDI incidence was highest among elderly adults (11.6 CDI discharges/1,000 total discharges), followed by adults, and pediatrics.
  • Higher rates of mortality were also highest among the elderly (8.8%), compared to adults (3.1%) and pediatrics (1.4%).
  • Median hospital LOS was highest in the elderly (8 days) compared to adults (7 days) and pediatrics (6 days).


Pechal A, Lin K, Allen S, Reveles K. National age group trends in Clostridium difficile infection incidence and health outcomes in United States community hospitals. [Published online ahead of print November 17, 2016]. BMC Infect Dis. doi:10.1186/s12879-016-2027-8.

This Week's Must Reads

Enterovirus in at-risk children associated with later celiac disease, Kahrs CR et al. BMJ. 2019 Feb 13. doi: 10.1136/bmj.l231

HCV-infected patients in the ED should be tested for advanced liver fibrosis, Yu-Hsiang Hsieh Y-H. Am J Emerg Med. 2019;37[2]:286-90

Baby boomers account for more than 74% of chronic HCV cases, Moore KJ et al. J Infect Public Health. 2019 Jan-Feb;12(1):32-6.

Possible mechanism for fluoroquinolone-induced aortopathy uncovered, Guzzardi DG et al. J Thorac Cardiovasc Surg. 2019;157:109-19.

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Bloodstream Infections in Hospitalized Children, Clin Infect Dis; ePub 2018 Dec 9; Spaulding, et al

Disparities and Risk Factors for Septicemia Deaths , Open Forum Infect Dis; ePub 2018 Nov 15; Kempker, et al

Predicting Severe Outcomes in US Norovirus Outbreaks, J Infect Dis; ePub 2018 Nov 15; Burke, et al

GI Microbiota Disruption with CRPA in ICU Patients, Clin Infect Dis; ePub 2018 Nov 1; Pettigrew, et al

Better Management of OPAT Can Reduce Readmissions, Clin Infect Dis; ePub 2018 Sep 21; Shah, et al