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Bloodstream Infections in Hospitalized Children

Clin Infect Dis; ePub 2018 Dec 9; Spaulding, et al

In the US, trends in hospitalization rates among pediatric bloodstream infections (BSIs) vary by pathogen and regionally, while overall BSI hospitalization rates did not significantly decline from 2009‒2016, a new study found. Researchers conducted a retrospective cohort study from 2009‒2016 utilizing demographic and microbiology data on inpatients aged <19 years using the Premier Healthcare Database. Hospitalization rate was the number of BSI-positive encounters per 1,000 admissions. They found:

  • Among 1,809,751 inpatients encounters from 162 US hospitals, 5,340 (0.30%) had a positive BSI, with community-acquired infections (CAIs) the most common.
  • BSI patients were more often aged 1‒5 years and had a complex chronic condition or central line compared to non-BSI patients.
  • BSI hospitalization rate declined non-significantly over time.
  • Among pathogens, E. coli, methicillin-sensitive Staphylococcus aureus, and Group A Streptococcus significantly increased for non-neonates.


Spaulding AB, Watson D, Dreyfus J, et al. Epidemiology of bloodstream infections in hospitalized children in the United States, 2009–2016. [Published online ahead of print December 9, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy1030.