Key clinical point: Oral rotavirus vaccination had a strong protective effect against laboratory-confirmed rotavirus infection in the first 2 years of the U.K. infant immunization program.
Major finding: Vaccine effectiveness was 69% for one dose and 77% for two doses.
Study details: Analyses of rotavirus vaccine effectiveness in the public health setting using laboratory surveillance data for 1,869 children and electronic health data on 40,723 children.
Disclosures: Funding came from the National Institute for Health Research Health Protection Research Unit in Immunisation at the London School of Hygiene and Tropical Medicine in partnership with Public Health England. The Immunisation and Countermeasures Division of Public Health England provided vaccine manufacturers with postmarketing surveillance reports.
Walker JL et al. Vaccine: X. 2019 Apr 11. doi: 10.1016/j.jvacx.2019.100005.